Telomerase as an Androgen Receptor-Regulated Target in Selenium Chemoprevention of Prostate Cancer

Telomerase as an Androgen Receptor-Regulated Target in Selenium Chemoprevention of Prostate Cancer PRINCIPAL INVESTIGATOR:

TITLE: GKLF as a Novel Target in Selenium Chemoprevention of Prostate Cancer

Our previous report showed that methylseleninic acid (MSA) significantly decreases the expression of androgen receptor and prostate-specific antigen (PSA) in LNCaP cells. The present study extended the above observations by showing the universality of this phenomenon and that the inhibitory effect of MSA on prostate cancer cell growth and cancer-specific biomarkers is mediated through androgen ...

Mechanism of Selenium Chemoprevention and Therapy in Prostate Cancer

1. Lee SO, Chun JY, Nadiminty, N, and Gao AC. Selenium inhibits growth of LNCaP human prostate tumor accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). Innovative Minds in Prostate Cancer Today (IMPaCT) meeting. Proceedings P18-14, p206, Atlanta, GA, September 5-8, 2007.

Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate

BACKGROUND High dietary intake of selenium or soybean isoflavones reduces prostate cancer risk. These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate. METHODS Male Noble rats were exposed from conception until 200 days of age to diets co...

Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate.

To evaluate the potential efficacy of selenium and vitamin E as inhibitors of prostate carcinogenesis, four chemoprevention studies using a common protocol were done in a rat model of androgen-dependent prostate cancer. After stimulation of prostate epithelial cell proliferation by a sequential regimen of cyproterone acetate followed by testosterone propionate, male Wistar-Unilever rats receive...